The SNARE Vti1a-β is localized to small synaptic vesicles and participates in a novel SNARE complex. Computational identification of microRNA targets. 5′-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. Tsuboi, T., da Silva Xavier, G., Leclerc, I. Patch-clamp characterisation of omatostatin-secreting cells in intact mouse pancreatic islets. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. PLoS Biol 2, E98 (2004)īarg, S., Galvanovskis, J., Gopel, S. Sequence-specific inhibition of small RNA function. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. A uniform system for microRNA annotation. in Current Protocols in Molecular Biology (eds Ausubel, F. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. Role of microRNAs in plant and animal development. An extensive class of small RNAs in Caenorhabditis elegans. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Identification of novel genes coding for small expressed RNAs. Lagos-Quintana, M., Rauhut, R., Lendeckel, W. MicroRNAs: genomics, biogenesis, mechanism, and function. Thus, miR-375 is a regulator of insulin secretion and may thereby constitute a novel pharmacological target for the treatment of diabetes.īartel, D. Inhibition of Mtpn by small interfering (si)RNA mimicked the effects of miR-375 on glucose-stimulated insulin secretion and exocytosis. Myotrophin ( Mtpn) was predicted to be and validated as a target of miR-375. The mechanism by which secretion is modified by miR-375 is independent of changes in glucose metabolism or intracellular Ca 2+-signalling but correlated with a direct effect on insulin exocytosis. Here we show that overexpression of miR-375 suppressed glucose-induced insulin secretion, and conversely, inhibition of endogenous miR-375 function enhanced insulin secretion. To study the role of miRNAs in pancreatic endocrine cells we cloned and identified a novel, evolutionarily conserved and islet-specific miRNA ( miR-375). Several miRNAs in animals exhibit tissue-specific or developmental-stage-specific expression, indicating that they could play important roles in many biological processes 2, 3, 4. When this happens, the route to this host will be automatically deleted.MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression 1. This type of route has a timeout, seen in the Expire column, which is used if the host does not respond in a specific amount of time. The addresses beginning with 0:e0: are MAC addresses.įreeBSD will automatically identify any hosts, test0 in the example, on the local Ethernet and add a route for that host over the Ethernet interface, re0. This indicates that all traffic for this destination should be internal, rather than sending it out over the network. The interface specified in the Netif column for localhost is lo0, also known as the loopback device. The default route for a machine which itself is functioning as the gateway to the outside world will be the gateway machine at the Internet Service Provider (ISP). Common Address Redundancy Protocol (CARP) File and Print Services for Microsoft® Windows® Clients (Samba) Dynamic Host Configuration Protocol (DHCP) Lightweight Directory Access Protocol (LDAP) Locale Configuration for Specific Languages FreeBSD as a Guest on VMware Fusion for macOS® FreeBSD as a Guest on Parallels Desktop for macOS® RAID3 - Byte-level Striping with Dedicated Parity GEOM: Modular Disk Transformation Framework Installing Applications: Packages and Ports Network Interfaces, Accounts, Time Zone, Services and Hardening
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